Screen. Treat. Protect.

Now you can help maintain normal B12 levels without a needle. Eligen B12 is the first and only once-daily oral non-prescription tablet shown to normalize B12 levels without inconvenient injections.

Screen your patients. Treat them with Eligen B12. Protect them from the dangerous effects of B12 deficiency.

IN A CLINICAL TRIAL, B12-DEFICIENT PATIENTS RECEIVED EITHER ELIGEN B12™ OR IM B12, AND BOTH ACHIEVED NORMAL B12 LEVELS (N=48)1

pill image
how it compares graph
  • While the study population was relatively small and heterogeneous in both etiology and predisposing factors for B12 deficiency, the magnitude of the effect obtained in both treatment arms of this study was large2
  • All patients (100%) met the primary end points with no variance2

> Study Design

IN PATIENTS WHO ARE DEFICIENT IN B12, ELIGEN B12™ EFFECTIVELY REDUCED MMA AND HOMOCYSTEINE LEVELS1

Elevated levels of the metabolites MMA and homocysteine in patients have been recognized as a precursor to B12 deficiency3

mma levels
mma levels
  • Elevated methylmalonic acid (MMA) and homocysteine levels can be early markers for tissue B12 deficiency prior to hematologic manifestations3
  • Measuring for elevated MMA and homocysteine levels is a more sensitive way to screen for B12 deficiency3
  • Up to 50% of patients with subclinical B12 deficiency have normal B12 levels but elevated MMA and homocysteine levels3
  • As B12 levels begin to normalize, MMA and homocysteine levels decrease3
  • MMA and homocysteine levels were compared in Eligen B12™ and IM B12 patients1
  • MMA and homocysteine levels were similarly decreased in both the Eligen B12™ and IM B12 treatment groups1

> Study Design

ELIGEN B12™ DEMONSTRATED MORE THAN DOUBLE THE BIOAVAILABILITY OF A CONVENTIONAL OTC ORAL B12 SUPPLEMENT AT THE SAME DOSE IN HEALTHY MALE PATIENTS4

bio availability

> Study Design
  • Eligen B12™ bioavailability was significantly greater than OTC oral B12 bioavailability (P<0.05)3
    – 5.09% for Eligen B12™ and 2.16% for OTC oral B124
  • Unlike OTC oral B12, the uptake of Eligen B12™ may occur in the stomach and/or proximal small intestine in B12-deficient patients with low intrinsic factor2

References:

  1. 1. Castelli MC, Friedman K, Sherry J, et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011;33(3):358-371.e2.
  2. 2. Eligen B12 [Package Insert]. Roseland, NJ: Emisphere Technologies, Inc; October 2014.
  3. 3. Oh R, Brown DL. Vitamin B12 deficiency. Am Fam Physician. 2003;67(5):979-986.
  4. 4. Castelli MC, Wong DF, Friedman K, Riley MG. Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects. Clin Ther. 2011;33(7):934-945.
  5. 5. Medical Foods Guidance Documents & Regulatory Information. US Food and Drug Administration website. http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/MedicalFoods. Accessed December 15, 2014.

Learn about the risks of low B12 and how Eligen B12 can help.

video
b12 icon

Your patients may be at greater risk for clinically low B12 levels.

b12 icon

Get more information about how Eligen B12 can help.

A prescription medical food is an FDA product classification. Medical foods are formulated to be consumed or administered orally under medical supervision and are intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements are established by medical evaluation. Eligen B12™ is a medical food available by prescription for patients who have a medically diagnosed vitamin B12 deficiency, associated with a disease or condition, that cannot be managed by a modification of normal diet alone.1,4

Intended for U.S. Residents Only

Prescribing Information | Site Map | Emisphere Technologies

4 Becker Farm Road, Suite 103, Roseland NJ 07068
1-800-867-9967
April 2006 ELB034
Emisphere Technologies - All Rights Reserved. © 2017