Eligen B12

The first and only non-prescription tablet for people with clinical B12 deficiency.

Now you can help patients maintain normal B12 levels without a needle. Eligen B12 is the first and only once-daily oral non-prescription tablet shown to normalize B12 levels without inconvenient injections.

The Science of B12 Absorption

The Science of B12 Absorption

phase 1 phase 2 phase 3

B12 molecule.


B12 across the gastric lining.


B12, regardless of intrinsic factor.

Eligen Technology

Eligen® Technology is specifically designed to allow patients to absorb an oral B12 formulation independent of intrinsic factor.1

  • Does not modify the chemical structure of B122
  • Is an inactive ingredient in the body2
  • Eligen B12™ should be taken with 50 mL of water. The binding between SNAC (salcaprozate sodium) and Eligen B12™ is tenuous by design and if taken with large quantities of water could reduce the amount of Eligen B12™ that can pass through the gastric lining1

Eligen™ Technology uses SNAC, a carrier that helps chaperone B12 through the gastric lining.1

  • Allows patients who are unable to absorb B12 intestinally to still take oral medication to resolve their B12 deficiency3

Both the Eligen B12™ SNAC carrier and B12 have met the requirements of GRAS* status from the FDA.5


  1. 1. Eligen B12 [Package Insert]. Roseland, NJ: Emisphere Technologies, Inc; October 2014.
  2. 2. Data on file. Emisphere Technologies, Inc; June 12, 2012.
  3. 3. Castelli MC, Friedman K, Sherry J, et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011;33(3):358-371.e2
  4. 4. Medical Foods Guidance Documents & Regulatory Information. US Food and Drug Administration website. http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/MedicalFoods. Accessed December 15, 2014.
  5. 5. Ingredients, Packaging & Labeling. US Food and Drug Administration website. http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS. Accessed February 2, 2015.

Learn about the risks of low B12 and how Eligen B12 can help.

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Your patients may be at greater risk for clinically low B12 levels.

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Get more information about how Eligen B12 can help.

A prescription medical food is an FDA product classification. Medical foods are formulated to be consumed or administered orally under medical supervision and are intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements are established by medical evaluation. Eligen B12™ is a medical food available by prescription for patients who have a medically diagnosed vitamin B12 deficiency, associated with a disease or condition, that cannot be managed by a modification of normal diet alone.1,4